Unveiling the Efficacy of Surgery and Minimally Invasive Radiation Therapy for Breast Cancer: A Comprehensive Study of Mashhad, Iran from 2017 to 2020
Code: G-1031
Authors: Asieh S. Fattahi ©, Roham Salek, Mohammad Nasr Forghani, Maryam Emadzadeh, Mohammad Javad Daneshamooz, Ali Mehri ℗
Schedule: Wednesday 2023-12-06 10:45 on Unit Panel B
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Abstract:
Abstract
Aim: This study investigates the outcomes of breast-conserving surgery and minimally invasive radiation therapy for early-stage breast cancer, which are commonly performed in radiation therapy centers. Method and materials: A retrospective and prospective cohort study was conducted on 153 patients who underwent breast-conserving surgery with oncoplastic resection technique and sentinel axillary lymph node biopsy, followed by treatment with radiotherapy using the Zeiss Intrabeam device. Adverse events and breast cancer recurrence were assessed to evaluate the safety and efficacy of this therapeutic intervention. The collected information was analyzed using SPSS22 software. Results: The mean age of patients was 55.74± 8.89 years, and the duration to breast cancer diagnosis was 36.73±10.41 months. Of the adverse events, 61 (59.8%), 33 (32.4%), 3 (2.9%), and 5 (4.9%) patients were classified as stage 0, 1, 2, and 3, respectively. Invasive tumor recurrence and bedside tumor were observed in 10 (10.1%) and one (1%) patient, respectively. Positive HER2neu (p-value=0.04) and LVI (p-value=0.02) were significantly associated with three-year survival. Conclusion: Breast-conserving surgery and minimally invasive radiation therapy are associated with good treatment outcomes, acceptable three-year survival, and the lowest rates and degrees of complications for early-stage breast cancer. However, further studies with larger sample sizes and longer follow-up periods are necessary to validate these findings.
Keywords
Breast cancer, Radiotherapy, Minimally invasive, Radiation therapy
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